effects of the aromatase inhibitor, letrozol, on levels of serum 17β-estradiol (e2) and enzymes in rainbow trout (oncorhynchus mykiss walbaum) females

in the present study, changes of values of serum 17ß-estradiol (e2), asparate amino teransferase (ast), alanine amino transferase (alt) and lactate dehydrogenase (ldh) following intraperitoneal (i.p) injection with the aromatase inhibitor (ai) letrozole were investigated in rainbow trout (oncorhynchus mykiss). forty- eight apparently healthy rainbow trout (mean weight of 845 g) divided in four groups (twelve fish for each group). (1) control vehicle injected, (2) group treated once with 1.0 mg ai kg-1, (3) group treated once with 2.5 mg ai/ kg and (4) group treated with 2.5 mg ai/ kg weekly (3×2.5 mg ai/ kg. results revealed that that, in the group injected weekly, serum e2 levels were significantly (p